PhytophthoraV1, Main, Exploration, bibRecord, 000597

A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.

Identifieur interne : 000597 ( Main/Exploration ); précédent : 000596; suivant : 000598

A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.

Auteurs : Yingnan Hou [États-Unis] ; Yi Zhai [États-Unis] ; Li Feng [République populaire de Chine] ; Hana Z. Karimi [États-Unis] ; Brian D. Rutter [États-Unis] ; Liping Zeng [États-Unis] ; Du Seok Choi [États-Unis] ; Bailong Zhang [États-Unis] ; Weifeng Gu [États-Unis] ; Xuemei Chen [États-Unis] ; Wenwu Ye [République populaire de Chine] ; Roger W. Innes [États-Unis] ; Jixian Zhai [République populaire de Chine] ; Wenbo Ma [États-Unis]

Source :

Cell host & microbe [ 1934-6069 ] ; 2019.

RBID : pubmed:30595554

Descripteurs français

KwdFr :
- Arabidopsis (génétique), Arabidopsis (immunologie), Arabidopsis (microbiologie), Extinction de l'expression des gènes (MeSH), Facteurs de virulence (génétique), Facteurs de virulence (métabolisme), Feuilles de plante (immunologie), Feuilles de plante (microbiologie), Gènes rapporteurs (génétique), Immunité des plantes (génétique), Immunité des plantes (immunologie), Interactions hôte-pathogène (génétique), Interactions hôte-pathogène (immunologie), Interférence par ARN (immunologie), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Petit ARN interférent (biosynthèse), Petit ARN interférent (effets des médicaments et des substances chimiques), Petit ARN interférent (génétique), Phosphoprotein Phosphatases (antagonistes et inhibiteurs), Phosphoprotein Phosphatases (métabolisme), Phytophthora (métabolisme), Phytophthora (pathogénicité), Protéines d'Arabidopsis (génétique), Protéines de liaison à l'ARN (génétique), Protéines de liaison à l'ARN (métabolisme), Prédisposition aux maladies (microbiologie), Régulation de l'expression des gènes végétaux (MeSH), Tabac (MeSH), Verticillium (MeSH), Virulence (MeSH), microARN (génétique), microARN (immunologie).
MESH :
- antagonistes et inhibiteurs : Phosphoprotein Phosphatases.
- biosynthèse : Petit ARN interférent.
- effets des médicaments et des substances chimiques : Petit ARN interférent.
- génétique : Arabidopsis, Facteurs de virulence, Gènes rapporteurs, Immunité des plantes, Interactions hôte-pathogène, Petit ARN interférent, Protéines d'Arabidopsis, Protéines de liaison à l'ARN, microARN.
- immunologie : Arabidopsis, Feuilles de plante, Immunité des plantes, Interactions hôte-pathogène, Interférence par ARN, Maladies des plantes, microARN.
- microbiologie : Arabidopsis, Feuilles de plante, Maladies des plantes, Prédisposition aux maladies.
- métabolisme : Facteurs de virulence, Phosphoprotein Phosphatases, Phytophthora, Protéines de liaison à l'ARN.
- pathogénicité : Phytophthora.
- Extinction de l'expression des gènes, Régulation de l'expression des gènes végétaux, Tabac, Verticillium, Virulence.

English descriptors

KwdEn :
- Arabidopsis (genetics), Arabidopsis (immunology), Arabidopsis (microbiology), Arabidopsis Proteins (genetics), Disease Susceptibility (microbiology), Gene Expression Regulation, Plant (MeSH), Gene Silencing (MeSH), Genes, Reporter (genetics), Host-Pathogen Interactions (genetics), Host-Pathogen Interactions (immunology), MicroRNAs (genetics), MicroRNAs (immunology), Phosphoprotein Phosphatases (antagonists & inhibitors), Phosphoprotein Phosphatases (metabolism), Phytophthora (metabolism), Phytophthora (pathogenicity), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Immunity (genetics), Plant Immunity (immunology), Plant Leaves (immunology), Plant Leaves (microbiology), RNA Interference (immunology), RNA, Small Interfering (biosynthesis), RNA, Small Interfering (drug effects), RNA, Small Interfering (genetics), RNA-Binding Proteins (genetics), RNA-Binding Proteins (metabolism), Tobacco (MeSH), Verticillium (MeSH), Virulence (MeSH), Virulence Factors (genetics), Virulence Factors (metabolism).
MESH :
- chemical , antagonists & inhibitors : Phosphoprotein Phosphatases.
- chemical , biosynthesis : RNA, Small Interfering.
- chemical , drug effects : RNA, Small Interfering.
- chemical , genetics : Arabidopsis Proteins, MicroRNAs, RNA, Small Interfering, RNA-Binding Proteins, Virulence Factors.
- genetics : Arabidopsis, Genes, Reporter, Host-Pathogen Interactions, Plant Immunity.
- immunology : Arabidopsis, Host-Pathogen Interactions, MicroRNAs, Plant Diseases, Plant Immunity, Plant Leaves, RNA Interference.
- chemical , metabolism : Phosphoprotein Phosphatases, Phytophthora, RNA-Binding Proteins, Virulence Factors.
- microbiology : Arabidopsis, Disease Susceptibility, Plant Diseases, Plant Leaves.
- pathogenicity : Phytophthora.
- Gene Expression Regulation, Plant, Gene Silencing, Tobacco, Verticillium, Virulence.

Abstract

RNA silencing (RNAi) has a well-established role in anti-viral immunity in plants. The destructive eukaryotic pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility. However, the role of small RNAs in defense against eukaryotic pathogens is unclear. Here, we show that Phytophthora infection of Arabidopsis leads to increased production of a diverse pool of secondary small interfering RNAs (siRNAs). Instead of regulating endogenous plant genes, these siRNAs are found in extracellular vesicles and likely silence target genes in Phytophthora during natural infection. Introduction of a plant siRNA in Phytophthora leads to developmental deficiency and abolishes virulence, while Arabidopsis mutants defective in secondary siRNA biogenesis are hypersusceptible. Notably, Phytophthora effector PSR2 specifically inhibits secondary siRNA biogenesis in Arabidopsis and promotes infection. These findings uncover the role of siRNAs as antimicrobial agents against eukaryotic pathogens and highlight a defense/counter-defense arms race centered on trans-kingdom gene silencing between hosts and pathogens.

DOI: 10.1016/j.chom.2018.11.007
PubMed: 30595554

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000585
to stream Main, to step Curation: 000585

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.</title>
<author><name sortKey="Hou, Yingnan" sort="Hou, Yingnan" uniqKey="Hou Y" first="Yingnan" last="Hou">Yingnan Hou</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhai, Yi" sort="Zhai, Yi" uniqKey="Zhai Y" first="Yi" last="Zhai">Yi Zhai</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Li" sort="Feng, Li" uniqKey="Feng L" first="Li" last="Feng">Li Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karimi, Hana Z" sort="Karimi, Hana Z" uniqKey="Karimi H" first="Hana Z" last="Karimi">Hana Z. Karimi</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Indiana University, Bloomington, IN 47405</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rutter, Brian D" sort="Rutter, Brian D" uniqKey="Rutter B" first="Brian D" last="Rutter">Brian D. Rutter</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Indiana University, Bloomington, IN 47405</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zeng, Liping" sort="Zeng, Liping" uniqKey="Zeng L" first="Liping" last="Zeng">Liping Zeng</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Du Seok" sort="Choi, Du Seok" uniqKey="Choi D" first="Du Seok" last="Choi">Du Seok Choi</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Bailong" sort="Zhang, Bailong" uniqKey="Zhang B" first="Bailong" last="Zhang">Bailong Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gu, Weifeng" sort="Gu, Weifeng" uniqKey="Gu W" first="Weifeng" last="Gu">Weifeng Gu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Xuemei" sort="Chen, Xuemei" uniqKey="Chen X" first="Xuemei" last="Chen">Xuemei Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Innes, Roger W" sort="Innes, Roger W" uniqKey="Innes R" first="Roger W" last="Innes">Roger W. Innes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Indiana University, Bloomington, IN 47405</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhai, Jixian" sort="Zhai, Jixian" uniqKey="Zhai J" first="Jixian" last="Zhai">Jixian Zhai</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Wenbo" sort="Ma, Wenbo" uniqKey="Ma W" first="Wenbo" last="Ma">Wenbo Ma</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: wenbo.ma@ucr.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30595554</idno>
<idno type="pmid">30595554</idno>
<idno type="doi">10.1016/j.chom.2018.11.007</idno>
<idno type="wicri:Area/Main/Corpus">000585</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000585</idno>
<idno type="wicri:Area/Main/Curation">000585</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000585</idno>
<idno type="wicri:Area/Main/Exploration">000585</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.</title>
<author><name sortKey="Hou, Yingnan" sort="Hou, Yingnan" uniqKey="Hou Y" first="Yingnan" last="Hou">Yingnan Hou</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhai, Yi" sort="Zhai, Yi" uniqKey="Zhai Y" first="Yi" last="Zhai">Yi Zhai</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Li" sort="Feng, Li" uniqKey="Feng L" first="Li" last="Feng">Li Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karimi, Hana Z" sort="Karimi, Hana Z" uniqKey="Karimi H" first="Hana Z" last="Karimi">Hana Z. Karimi</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Indiana University, Bloomington, IN 47405</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rutter, Brian D" sort="Rutter, Brian D" uniqKey="Rutter B" first="Brian D" last="Rutter">Brian D. Rutter</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Indiana University, Bloomington, IN 47405</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zeng, Liping" sort="Zeng, Liping" uniqKey="Zeng L" first="Liping" last="Zeng">Liping Zeng</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Du Seok" sort="Choi, Du Seok" uniqKey="Choi D" first="Du Seok" last="Choi">Du Seok Choi</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Bailong" sort="Zhang, Bailong" uniqKey="Zhang B" first="Bailong" last="Zhang">Bailong Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gu, Weifeng" sort="Gu, Weifeng" uniqKey="Gu W" first="Weifeng" last="Gu">Weifeng Gu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Xuemei" sort="Chen, Xuemei" uniqKey="Chen X" first="Xuemei" last="Chen">Xuemei Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Innes, Roger W" sort="Innes, Roger W" uniqKey="Innes R" first="Roger W" last="Innes">Roger W. Innes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Indiana University, Bloomington, IN 47405</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhai, Jixian" sort="Zhai, Jixian" uniqKey="Zhai J" first="Jixian" last="Zhai">Jixian Zhai</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Wenbo" sort="Ma, Wenbo" uniqKey="Ma W" first="Wenbo" last="Ma">Wenbo Ma</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: wenbo.ma@ucr.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell host & microbe</title>
<idno type="eISSN">1934-6069</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arabidopsis (genetics)</term>
<term>Arabidopsis (immunology)</term>
<term>Arabidopsis (microbiology)</term>
<term>Arabidopsis Proteins (genetics)</term>
<term>Disease Susceptibility (microbiology)</term>
<term>Gene Expression Regulation, Plant (MeSH)</term>
<term>Gene Silencing (MeSH)</term>
<term>Genes, Reporter (genetics)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Host-Pathogen Interactions (immunology)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (immunology)</term>
<term>Phosphoprotein Phosphatases (antagonists & inhibitors)</term>
<term>Phosphoprotein Phosphatases (metabolism)</term>
<term>Phytophthora (metabolism)</term>
<term>Phytophthora (pathogenicity)</term>
<term>Plant Diseases (immunology)</term>
<term>Plant Diseases (microbiology)</term>
<term>Plant Immunity (genetics)</term>
<term>Plant Immunity (immunology)</term>
<term>Plant Leaves (immunology)</term>
<term>Plant Leaves (microbiology)</term>
<term>RNA Interference (immunology)</term>
<term>RNA, Small Interfering (biosynthesis)</term>
<term>RNA, Small Interfering (drug effects)</term>
<term>RNA, Small Interfering (genetics)</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>RNA-Binding Proteins (metabolism)</term>
<term>Tobacco (MeSH)</term>
<term>Verticillium (MeSH)</term>
<term>Virulence (MeSH)</term>
<term>Virulence Factors (genetics)</term>
<term>Virulence Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Arabidopsis (génétique)</term>
<term>Arabidopsis (immunologie)</term>
<term>Arabidopsis (microbiologie)</term>
<term>Extinction de l'expression des gènes (MeSH)</term>
<term>Facteurs de virulence (génétique)</term>
<term>Facteurs de virulence (métabolisme)</term>
<term>Feuilles de plante (immunologie)</term>
<term>Feuilles de plante (microbiologie)</term>
<term>Gènes rapporteurs (génétique)</term>
<term>Immunité des plantes (génétique)</term>
<term>Immunité des plantes (immunologie)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Interactions hôte-pathogène (immunologie)</term>
<term>Interférence par ARN (immunologie)</term>
<term>Maladies des plantes (immunologie)</term>
<term>Maladies des plantes (microbiologie)</term>
<term>Petit ARN interférent (biosynthèse)</term>
<term>Petit ARN interférent (effets des médicaments et des substances chimiques)</term>
<term>Petit ARN interférent (génétique)</term>
<term>Phosphoprotein Phosphatases (antagonistes et inhibiteurs)</term>
<term>Phosphoprotein Phosphatases (métabolisme)</term>
<term>Phytophthora (métabolisme)</term>
<term>Phytophthora (pathogénicité)</term>
<term>Protéines d'Arabidopsis (génétique)</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Protéines de liaison à l'ARN (métabolisme)</term>
<term>Prédisposition aux maladies (microbiologie)</term>
<term>Régulation de l'expression des gènes végétaux (MeSH)</term>
<term>Tabac (MeSH)</term>
<term>Verticillium (MeSH)</term>
<term>Virulence (MeSH)</term>
<term>microARN (génétique)</term>
<term>microARN (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Phosphoprotein Phosphatases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arabidopsis Proteins</term>
<term>MicroRNAs</term>
<term>RNA, Small Interfering</term>
<term>RNA-Binding Proteins</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Phosphoprotein Phosphatases</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Petit ARN interférent</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Petit ARN interférent</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabidopsis</term>
<term>Genes, Reporter</term>
<term>Host-Pathogen Interactions</term>
<term>Plant Immunity</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arabidopsis</term>
<term>Facteurs de virulence</term>
<term>Gènes rapporteurs</term>
<term>Immunité des plantes</term>
<term>Interactions hôte-pathogène</term>
<term>Petit ARN interférent</term>
<term>Protéines d'Arabidopsis</term>
<term>Protéines de liaison à l'ARN</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Arabidopsis</term>
<term>Feuilles de plante</term>
<term>Immunité des plantes</term>
<term>Interactions hôte-pathogène</term>
<term>Interférence par ARN</term>
<term>Maladies des plantes</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arabidopsis</term>
<term>Host-Pathogen Interactions</term>
<term>MicroRNAs</term>
<term>Plant Diseases</term>
<term>Plant Immunity</term>
<term>Plant Leaves</term>
<term>RNA Interference</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phosphoprotein Phosphatases</term>
<term>Phytophthora</term>
<term>RNA-Binding Proteins</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Arabidopsis</term>
<term>Feuilles de plante</term>
<term>Maladies des plantes</term>
<term>Prédisposition aux maladies</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Arabidopsis</term>
<term>Disease Susceptibility</term>
<term>Plant Diseases</term>
<term>Plant Leaves</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de virulence</term>
<term>Phosphoprotein Phosphatases</term>
<term>Phytophthora</term>
<term>Protéines de liaison à l'ARN</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Plant</term>
<term>Gene Silencing</term>
<term>Tobacco</term>
<term>Verticillium</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Extinction de l'expression des gènes</term>
<term>Régulation de l'expression des gènes végétaux</term>
<term>Tabac</term>
<term>Verticillium</term>
<term>Virulence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">RNA silencing (RNAi) has a well-established role in anti-viral immunity in plants. The destructive eukaryotic pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility. However, the role of small RNAs in defense against eukaryotic pathogens is unclear. Here, we show that Phytophthora infection of Arabidopsis leads to increased production of a diverse pool of secondary small interfering RNAs (siRNAs). Instead of regulating endogenous plant genes, these siRNAs are found in extracellular vesicles and likely silence target genes in Phytophthora during natural infection. Introduction of a plant siRNA in Phytophthora leads to developmental deficiency and abolishes virulence, while Arabidopsis mutants defective in secondary siRNA biogenesis are hypersusceptible. Notably, Phytophthora effector PSR2 specifically inhibits secondary siRNA biogenesis in Arabidopsis and promotes infection. These findings uncover the role of siRNAs as antimicrobial agents against eukaryotic pathogens and highlight a defense/counter-defense arms race centered on trans-kingdom gene silencing between hosts and pathogens.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30595554</PMID>
<DateCompleted><Year>2019</Year>
<Month>03</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1934-6069</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>01</Month>
<Day>09</Day>
</PubDate>
</JournalIssue>
<Title>Cell host & microbe</Title>
<ISOAbbreviation>Cell Host Microbe</ISOAbbreviation>
</Journal>
<ArticleTitle>A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.</ArticleTitle>
<Pagination><MedlinePgn>153-165.e5</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1931-3128(18)30589-4</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chom.2018.11.007</ELocationID>
<Abstract><AbstractText>RNA silencing (RNAi) has a well-established role in anti-viral immunity in plants. The destructive eukaryotic pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility. However, the role of small RNAs in defense against eukaryotic pathogens is unclear. Here, we show that Phytophthora infection of Arabidopsis leads to increased production of a diverse pool of secondary small interfering RNAs (siRNAs). Instead of regulating endogenous plant genes, these siRNAs are found in extracellular vesicles and likely silence target genes in Phytophthora during natural infection. Introduction of a plant siRNA in Phytophthora leads to developmental deficiency and abolishes virulence, while Arabidopsis mutants defective in secondary siRNA biogenesis are hypersusceptible. Notably, Phytophthora effector PSR2 specifically inhibits secondary siRNA biogenesis in Arabidopsis and promotes infection. These findings uncover the role of siRNAs as antimicrobial agents against eukaryotic pathogens and highlight a defense/counter-defense arms race centered on trans-kingdom gene silencing between hosts and pathogens.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hou</LastName>
<ForeName>Yingnan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhai</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karimi</LastName>
<ForeName>Hana Z</ForeName>
<Initials>HZ</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rutter</LastName>
<ForeName>Brian D</ForeName>
<Initials>BD</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Liping</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Choi</LastName>
<ForeName>Du Seok</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Bailong</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gu</LastName>
<ForeName>Weifeng</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Xuemei</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Wenwu</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Innes</LastName>
<ForeName>Roger W</ForeName>
<Initials>RW</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhai</LastName>
<ForeName>Jixian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Wenbo</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: wenbo.ma@ucr.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>12</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Cell Host Microbe</MedlineTA>
<NlmUniqueID>101302316</NlmUniqueID>
<ISSNLinking>1931-3128</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029681">Arabidopsis Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C511456">DRB4 protein, Arabidopsis</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D037521">Virulence Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C538752">pentatricopeptide repeat protein, Arabidopsis</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.16</RegistryNumber>
<NameOfSubstance UI="D010749">Phosphoprotein Phosphatases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Cell Host Microbe. 2019 Jan 9;25(1):7-9</RefSource>
<PMID Version="1">30629921</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029681" MajorTopicYN="N">Arabidopsis Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020868" MajorTopicYN="N">Gene Silencing</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017930" MajorTopicYN="N">Genes, Reporter</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D035683" MajorTopicYN="N">MicroRNAs</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010749" MajorTopicYN="N">Phosphoprotein Phosphatases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018515" MajorTopicYN="N">Plant Leaves</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020172" MajorTopicYN="N">Verticillium</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037521" MajorTopicYN="N">Virulence Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">RNA interference</Keyword>
<Keyword MajorTopicYN="Y">RNA-silencing suppressor</Keyword>
<Keyword MajorTopicYN="Y">host-induced gene silencing</Keyword>
<Keyword MajorTopicYN="Y">microRNA</Keyword>
<Keyword MajorTopicYN="Y">pathogenesis</Keyword>
<Keyword MajorTopicYN="Y">plant immunity</Keyword>
<Keyword MajorTopicYN="Y">secondary small RNAs</Keyword>
<Keyword MajorTopicYN="Y">virulence factor</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>07</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>10</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>10</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>3</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30595554</ArticleId>
<ArticleId IdType="pii">S1931-3128(18)30589-4</ArticleId>
<ArticleId IdType="doi">10.1016/j.chom.2018.11.007</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Guangdong</li>
<li>Indiana</li>
</region>
<settlement><li>Shenzhen</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Hou, Yingnan" sort="Hou, Yingnan" uniqKey="Hou Y" first="Yingnan" last="Hou">Yingnan Hou</name>
</region>
<name sortKey="Chen, Xuemei" sort="Chen, Xuemei" uniqKey="Chen X" first="Xuemei" last="Chen">Xuemei Chen</name>
<name sortKey="Choi, Du Seok" sort="Choi, Du Seok" uniqKey="Choi D" first="Du Seok" last="Choi">Du Seok Choi</name>
<name sortKey="Gu, Weifeng" sort="Gu, Weifeng" uniqKey="Gu W" first="Weifeng" last="Gu">Weifeng Gu</name>
<name sortKey="Innes, Roger W" sort="Innes, Roger W" uniqKey="Innes R" first="Roger W" last="Innes">Roger W. Innes</name>
<name sortKey="Karimi, Hana Z" sort="Karimi, Hana Z" uniqKey="Karimi H" first="Hana Z" last="Karimi">Hana Z. Karimi</name>
<name sortKey="Ma, Wenbo" sort="Ma, Wenbo" uniqKey="Ma W" first="Wenbo" last="Ma">Wenbo Ma</name>
<name sortKey="Rutter, Brian D" sort="Rutter, Brian D" uniqKey="Rutter B" first="Brian D" last="Rutter">Brian D. Rutter</name>
<name sortKey="Zeng, Liping" sort="Zeng, Liping" uniqKey="Zeng L" first="Liping" last="Zeng">Liping Zeng</name>
<name sortKey="Zhai, Yi" sort="Zhai, Yi" uniqKey="Zhai Y" first="Yi" last="Zhai">Yi Zhai</name>
<name sortKey="Zhang, Bailong" sort="Zhang, Bailong" uniqKey="Zhang B" first="Bailong" last="Zhang">Bailong Zhang</name>
</country>
<country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Feng, Li" sort="Feng, Li" uniqKey="Feng L" first="Li" last="Feng">Li Feng</name>
</region>
<name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
<name sortKey="Zhai, Jixian" sort="Zhai, Jixian" uniqKey="Zhai J" first="Jixian" last="Zhai">Jixian Zhai</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PhytophthoraV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000597 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000597 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    PhytophthoraV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30595554
   |texte=   A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30595554" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PhytophthoraV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Nov 20 11:20:57 2020. Site generation: Wed Mar 6 16:48:20 2024

	Serveur d'exploration Phytophthora
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Phytophthora

A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.

A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki